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dc.contributor.advisorHansen, Trond Vidar
dc.contributor.advisorStenstrøm, Yngve
dc.contributor.authorRasmussen, Jeanne Sønderskov
dc.date.accessioned2019-07-17T11:39:33Z
dc.date.available2019-07-17T11:39:33Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/11250/2605665
dc.description.abstractThis master thesis presents the first synthesis of the methyl ester of the specialized pro-resolving mediator named MaR2n-3 DPA. The stereoselective synthesis is based on a Z-selective Lindlar reaction, a Sonogashira coupling reaction and a Takai olefination, as the key steps. These efforts resulted in a satisfactory synthesis of the methyl ester of MaR2n-3 DPA in 12 steps and in 95% purity, affording multi milligrams of the material. Synthesis of the free acid of MaR2n-3 DPA was achieved, however, due to limited time period not in an acceptable degree of purity.nb_NO
dc.language.isoengnb_NO
dc.publisherNorwegian University of Life Sciences, Åsnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.subjectSPMnb_NO
dc.subjectMaR2n-3 DPAnb_NO
dc.subjectn-3 DPAnb_NO
dc.subjectn-3 DPA derived mediatorsnb_NO
dc.subjectSpecialized pro-resolving mediatorsnb_NO
dc.subjectMaresinnb_NO
dc.subjectLipid mediatorsnb_NO
dc.subjectInflammationnb_NO
dc.titleSynthesis of the Methyl Ester of MaR2n-3 DPAnb_NO
dc.title.alternativeSyntese av metylesteren av MaR2n-3 DPAnb_NO
dc.typeMaster thesisnb_NO
dc.description.versionsubmittedVersionnb_NO
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400nb_NO
dc.source.pagenumber124nb_NO
dc.description.localcodeM-KBnb_NO


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal