Browsing Doctoral theses (KBM) by Title
Now showing items 101-120 of 121
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The site-2-protease RseP as a novel antimicrobial target
(PhD Thesis;2023:22, Doctoral thesis, 2023)The discovery and development of antibiotics have revolutionized modern medicine. Today, several decades after the first patients were treated with antibiotics, bacterial infections are again becoming increasingly difficult ... -
Small intestinal microbiota – Regulation by reactive oxygen species and influence of diet
(PhD Thesis;2022:5, Doctoral thesis, 2022)Over the last years multiple studies have analyzed the impact of intestinal microbiota on health. Certain changes in the composition of the microbial population in the intestine have been associated with several diseases ... -
Spread and persistence of antibiotic resistance genes in the honeybee gut microbiota
(PhD Thesis;2018:26, Doctoral thesis, 2018)Bacteria residing in the gut – the gut microbiota (GM) – are important for host health. Several parallels between the human and honeybee GM exist: i) the GM is host specific (core microbiota), ii) age dependent development ... -
Staphylococcus aureus from milk and milk products in Ethiopia : prevalence, enterotoxigenic potential, antibiotic resistance and spa types
(PhD Thesis;2016:48, Doctoral thesis, 2017-12-12)Milk production in Ethiopia is increasing. However, due to unhygienic and traditional milk production and processing practices the issue of milk safety remains a challenge. If these safety issues are not properly addressed, ... -
Stress responses of Listeria monocytogenes to antimicrobial substances from lactic acid bacteria : an explorative study
(PhD Thesis;2011:02, Doctoral thesis, 2011)Listeria monocytogenes is a gram-positive bacterium that causes severe and life threatening disease both in humans and animals. Due to the severity of the disease and the fact that the bacterium is responsible for considerable ... -
Structural and functional characterization of NcLPMO9C : a broad-specificity lytic polysaccharide monooxygenase
(PhD Thesis;2017:93, Doctoral thesis, 2017)Lignocellulose represents a major source of renewable organic matter and is of interest as feedstock for the biorefining industry, not only as a promising strategy for replacing fossil fuels in the transportation sector ... -
Structural characterization of lignin and some side-products from steam-exploded woody biomass
(PhD Thesis;2018:91, Doctoral thesis, 2018)The main objective of this thesis was to make a platform of libraries for characterization of lignin and other side-products after steam-explosion. The complete and effective utilization of renewable biomass will be ... -
Structure, stability and digestion of caprine and bovine lactoferrin : a comparative study
(PhD Thesis;2011:01, Doctoral thesis, 2011)In this thesis, the structure, stability and digestion of caprine and bovine lactoferrin were compared. The work carried out in this project has been divided into four parts. A comparative study was done on the thermal ... -
Studies of molecular determinants of virulence in Aliivibrio salmonicida and Vibrio anguillarum
(PhD Thesis;2021:58, Doctoral thesis, 2021)The arsenal of virulence factors possessed by a bacterium can determine its ability to infect the host and cause disease. Chitinases and chitin-active lytic polysaccharide monooxygenases (LPMOs) have been indicated to ... -
Studies of proteins involved in environmental responses of Enterococcus faecalis V583
(PhD Thesis;2011:58, Doctoral thesis, 2011)Enterococcus faecalis has traditionally been considered a harmless inhabitant of the gastrointestinal tract of mammals. However, in the past decade E. faecalis has become a major cause of infections in hospitalized patients. ... -
Studies on bacteriophages infecting lactic acid bacteria of industrial food fermentations
(PhD Thesis;2012:17, Doctoral thesis, 2012)Industrial food fermentations by lactic acid bacteria (LAB) are of great practical and economic importance. Bacteriophages (phages; bacterial viruses) infecting LAB can negatively affect quality, safety and value of the ... -
Syntheses of 3-, 4- and 5-membered carbocycles : new methodology on old methods
(PhD Thesis;2015:94, Doctoral thesis, 2020-11-13)The main focus of this thesis was to use new methodology on already well-established methods of preparation of 3-membered, 4-membered and 5-membered carbocyclic compounds with the emphasis on improving them. Traditional ... -
Synthesis of some marine natural product fatty acid derivatives
(PhD Thesis;2016:74, Doctoral thesis, 2020-11-24)The research presented in this thesis puts forth total syntheses of two marine natural products: (-)-mucosin and (+)-crucigasterin 277. Both syntheses focus on producing enantiopure natural products derived from commercially ... -
Tailoring microalgal biomass for food applications : fermented beverage as a case study
(PhD Thesis;2022:19, Doctoral thesis, 2022)Microalgae are renowned as super-foods due to their unique nutritional profiles; however, their applications to human nutrition are still limited to nutraceuticals and food supplements. This is likely due to factors such ... -
Taste sensitivity and food liking in preadolescent children
(PhD Thesis;2021:83, Doctoral thesis, 2021)Taste is a key factor in determining food palatability and affects food acceptance. Children have been reported to have different taste sensitivity perceptions, which may influence their food preferences. The main objective ... -
The first stereoselective syntheses of (all-Z)- hentriaconta-3,6,9,12,15,19,22,25,28-nonaene and obscuraminol A, two polyunsaturated natural products
(PhD Thesis;2015:75, Doctoral thesis, 2018-12-19)The research described herein focuses on stereoselective synthesis of some Z-polyenoic natural products, making them available for biological studies. The objectives of the study can be subdivided into three parts integrated ... -
The Soil Bacterium Methylococcus capsulatus Bath and its Interactions with Human Immune Cells in vitro
(PhD Thesis;2017:94, Doctoral thesis, 2017)Whereas a role for commensal microbes in the development and normal function of the immune system is well established, a potential role for environmental bacteria in regulating immunity has been widely disregarded. However, ... -
Thermodynamic aspects of processive enzymatic degradation of recalcitrant polysaccharides
(PhD Thesis;2015:46, Doctoral thesis, 2020-11-13)Carbohydrates play diverse, essential roles in all known organisms. These include roles in storage and structure as well as specific signaling roles. One carbohydrate can be linked to other carbohydrates or functional ... -
Total synthesis as a tool for structural elucidation of some marine lipid natural products
(PhD Thesis;2017:32, Doctoral thesis, 2017)Paper I describes the total synthesis of the proposed structure of mucosin, a C20 fatty acid, isolated from a Mediterranean sponge, Reniera mucosa. The synthetic pathway started with the transformation of 1,4-cyclohexadiene ... -
Understanding and optimizing the role of lytic polysaccharide monooxygenases in enzymatic conversion of lignocellulosic biomass
(PhD Thesis;2022:31, Doctoral thesis, 2022)Lignocellulosic biomass holds great potential for production of biofuels and other chemicals traditionally produced from fossil fuels. However, its significant recalcitrance presents a substantial challenge in industrial ...