Browsing Doctoral theses (KBM) by Issue Date
Now showing items 1-20 of 128
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A study of mechanisms involved in the pathogenicity of Enterococcus faecalis by DNA microarrays
(PhD Thesis;2010:54, Doctoral thesis, 2010)Traditionally considered a harmless commensal of the mammalian gastrointestinal tract, Enterococcus faecalis now rank among the leading causes of nosocomial infections worldwide. Several genetic determinants enhancing the ... -
Lactobacillus sakei metabolism and diversity
(PhD Thesis;2010:21, Doctoral thesis, 2010)Lactic acid bacteria are associated with food fermentation, acidification and preservation. Lactobacillus sakei is an industrially important species mainly due to its ability to ferment and preserve meat. It is used as ... -
Molecular mechanisms of pneumococcal fratricide
(PhD Thesis;2010:13, Doctoral thesis, 2010)The bacterium Streptococcus pneumoniae is endowed with the ability to take up naked DNA from the surroundings and recombine this DNA into the chromosome. This property, termed competence for natural genetic transformation, ... -
Natural genetic transformation: development of a new genetic tool for Streptococcus thermophilus
(PhD Thesis;2010:16, Doctoral thesis, 2010)Lactic acid bacteria (LAB) have been used in fermentation of foods for hundreds or even thousands of years. During the last decade the genome sequences of a number of commercially important LAB species and strains have ... -
An explorative study of Enterococcus faecalis transcriptional responses to infection-relevant growth environments
(PhD Thesis;2010:10, Doctoral thesis, 2010)Enterococcus faecalis is commonly found in the gastrointestinal tract of humans. It is also an opportunistic pathogen and one of the leading causes of nosocomial infections worldwide. The treatment of E. faecalis infections ... -
Application of Bayesian calibration for propagation of uncertainty in dynamic models
(PhD Thesis;2010:8, Doctoral thesis, 2010)The thesis is about quantification of uncertainties in complex models. Models are built to describe, explain or predict a real world outcome. It is well known that models are related with uncertainty, and that uncertainties ... -
Consumer perception and acceptance of calorie-reduced dairy products
(PhD Thesis;2010:03, Doctoral thesis, 2010)This thesis is a part of the research project ‘‘Low energy products and consumer preferences”, financed by the Research Council of Norway (NFR) through Grant 167928/I10. The thesis is based on three experiments. Consumers’ ... -
In vitro digestion of caprine whey proteins by human gastrointestinal juices : Effect of whey hydrolysates and peptides on in vitro cell responses
(PhD Thesis;2011:70, Doctoral thesis, 2011)The objectives of this thesis were to characterise human gastrointestinal juices, to identify peptides produced after in vitro digestion of whey proteins by these juices, and to screen for immunomodulating properties of ... -
Studies of proteins involved in environmental responses of Enterococcus faecalis V583
(PhD Thesis;2011:58, Doctoral thesis, 2011)Enterococcus faecalis has traditionally been considered a harmless inhabitant of the gastrointestinal tract of mammals. However, in the past decade E. faecalis has become a major cause of infections in hospitalized patients. ... -
A detailed study of substrate positioning in family 18 chitinases
(PhD Thesis;2011:41, Doctoral thesis, 2011)Chitin is a linear polymer consisting of β-1,4-linked N-acetyl-glucosamine (GlcNAc; A) units tightly packed in a crystalline structure. It is produced by living organisms in large quantities per year and is a structural ... -
Minimizing photooxidation in dairy products by tailor made light barrier properties in packaging materials
(PhD Thesis;2011:47, Doctoral thesis, 2011)Photooxidation is one of the major causes of food quality deterioration. Packaging is a common tool to protect against light and consequently prolong the shelf life of food. Transparent packaging materials are being widely ... -
Regulation of energy metabolism in enterococcus faecalis studied by transcriptome, proteome and metabolome approaches
(PhD Thesis;2011:48, Doctoral thesis, 2011)Lactic Acid Bacteria (LAB) are widely used as starter culture in food fermentation. Among LAB also pathogenic bacteria are found particular in enterococci and streptococci. Enterococcus faecalis is a gut commensal bacterium ... -
Natural transformation in Streptococcus thermophilus : Regulation autolysis and ComS*-controlled gene expression.
(PhD Thesis;2011:67, Doctoral thesis, 2011)Natural genetic transformation has been extensively studied in Streptococcus pneumoniae for generations, and much has been learned about this important phenomenon since its discovery by Frederick Griffith in 1928. In ... -
Dissecting molecular properties of honey bee vitellogenin : a protein acting at the intersection between social behavior and aging
(PhD Thesis;2011:59, Doctoral thesis, 2011)Vitellogenin is a central honey bee (Apis mellifera) life-history regulator. This thesis represents an initiative to study this protein, which affects aging and task-division of the bees, at the molecular level. I have ... -
Stress responses of Listeria monocytogenes to antimicrobial substances from lactic acid bacteria : an explorative study
(PhD Thesis;2011:02, Doctoral thesis, 2011)Listeria monocytogenes is a gram-positive bacterium that causes severe and life threatening disease both in humans and animals. Due to the severity of the disease and the fact that the bacterium is responsible for considerable ... -
Multivariate analysis as a tool for understanding and reducing complexity of mathematical models in systems biology
(PhD Thesis;2011:34, Doctoral thesis, 2011)In the area of systems biology, technologies develop very fast, which allows us to collect massive amounts of various data. The main interest of scientists is to receive an insight into the obtained data sets and discover ... -
Knowledge-based methods handling complex dependency structures : applications to gene expression data
(PhD Thesis;2011:46, Doctoral thesis, 2011)Microarray gene expression data are usually associated with a large number of correlated variables measured on few samples. This type of data typically contain high levels of noise, and the biological signals may be difficult ... -
Identification of androstenone sensitive subjects and their evaluation of different androstenone and skatole tainted meat products
(PhD Thesis;2011:12, Doctoral thesis, 2011)Castration of entire male pigs is widely used in Norway to prevent the unpleasant odour/flavour that may occur in meat from boars. Castration of entire male pigs is expected to be prohibited in Norway (and in Europe) in ... -
Structure, stability and digestion of caprine and bovine lactoferrin : a comparative study
(PhD Thesis;2011:01, Doctoral thesis, 2011)In this thesis, the structure, stability and digestion of caprine and bovine lactoferrin were compared. The work carried out in this project has been divided into four parts. A comparative study was done on the thermal ... -
Class II bacteriocins : target recognition, resistance and immunity
(PhD Thesis;2011:11, Doctoral thesis, 2011)Bacteriocins are bacterial antimicrobial peptides which are active against strains often closely related to the producer. Bacteriocins produced by food grade lactic acid bacteria are considered promising for applications ...