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dc.contributor.authorMcGlinchey, Aidan
dc.contributor.authorSinioja, Tim
dc.contributor.authorLamichhane, Santosh
dc.contributor.authorSen, Partho
dc.contributor.authorBodin, Johanna Eva
dc.contributor.authorSiljander, Heli
dc.contributor.authorDickens, Alex M.
dc.contributor.authorGeng, Dawei
dc.contributor.authorCarlsson, Cecilia
dc.contributor.authorDuberg, Daniel
dc.contributor.authorIlonen, Jorma
dc.contributor.authorVirtanen, Suvi M.
dc.contributor.authorDirven, Hubert
dc.contributor.authorBerntsen, Hanne Friis
dc.contributor.authorZimmer, Karin Elisabeth
dc.contributor.authorNygaard, Unni Cecilie
dc.contributor.authorOrešič, Matej
dc.contributor.authorKnip, Mikael
dc.contributor.authorHyötyläinen, Tuulia
dc.date.accessioned2021-11-18T08:29:48Z
dc.date.available2021-11-18T08:29:48Z
dc.date.created2020-07-21T12:16:47Z
dc.date.issued2020
dc.identifier.citationEnvironment International. 2020, 143 .
dc.identifier.issn0160-4120
dc.identifier.urihttps://hdl.handle.net/11250/2830207
dc.description.abstractIn the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
dc.language.isoeng
dc.titlePrenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber14
dc.source.volume143
dc.source.journalEnvironment International
dc.identifier.doi10.1016/j.envint.2020.105935
dc.identifier.cristin1820015
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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