dc.contributor.author | Kannimuthu, Dhamotharan | |
dc.contributor.author | Tengs, Torstein | |
dc.contributor.author | Wessel, Øystein | |
dc.contributor.author | Braaen, Stine | |
dc.contributor.author | Nyman, Ingvild Berg | |
dc.contributor.author | Hansen, Elisabeth Furuseth | |
dc.contributor.author | Christiansen, Debes H. | |
dc.contributor.author | Dahle, Maria | |
dc.contributor.author | Rimstad, Espen | |
dc.contributor.author | Markussen, Turhan Ali Dadasbilge | |
dc.date.accessioned | 2019-09-18T08:10:03Z | |
dc.date.available | 2019-09-18T08:10:03Z | |
dc.date.created | 2019-09-11T16:21:36Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Viruses. 2019, 11 (5), 1-16. | nb_NO |
dc.identifier.issn | 1999-4915 | |
dc.identifier.uri | http://hdl.handle.net/11250/2617366 | |
dc.description.abstract | Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 genomes collected over a 30-year period from fish with or without HSMI, grouped the viral sequences into two main monophylogenetic clusters, one associated with HSMI and the other with low virulent PRV-1 isolates. A PRV-1 strain from Norway sampled in 1988, a decade before the emergence of HSMI, grouped with the low virulent HSMI cluster. The two distinct monophylogenetic clusters were particularly evident for segments S1 and M2. Only a limited number of amino acids were unique to the association with HSMI, and they all located to S1 and M2 encoded proteins. The observed co-evolution of the S1-M2 pair coincided in time with the emergence of HSMI in Norway, and may have evolved through accumulation of mutations and/or segment reassortment. Sequences of S1-M2 suggest selection of the HSMI associated pair, and that this segment pair has remained almost unchanged in Norwegian salmon aquaculture since 1997. PRV-1 strains from the North American Pacific Coast and Faroe Islands have not undergone this evolution, and are more closely related to the PRV-1 precursor strains not associated with clinical HSMI. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Evolution of the Piscine orthoreovirus genome linked to emergence of heart and skeletal muscle inflammation in farmed Atlantic Salmon (Salmo salar) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-16 | nb_NO |
dc.source.volume | 11:465 | nb_NO |
dc.source.journal | Viruses | nb_NO |
dc.source.issue | 5 | nb_NO |
dc.identifier.doi | 10.3390/v11050465 | |
dc.identifier.cristin | 1723755 | |
cristin.unitcode | 192,16,2,0 | |
cristin.unitcode | 192,12,0,0 | |
cristin.unitname | Institutt for mattrygghet og infeksjonsbiologi | |
cristin.unitname | Kjemi, bioteknologi og matvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |