dc.contributor.author | Vendramin, Niccoló | |
dc.contributor.author | Kannimuthu, Dhamotharan | |
dc.contributor.author | Olsen, Anne Berit | |
dc.contributor.author | Cuenca, Argelia | |
dc.contributor.author | Teige, Lena Hammerlund | |
dc.contributor.author | Wessel, Øystein | |
dc.contributor.author | Iburg, Tine Moesgaard | |
dc.contributor.author | Dahle, Maria | |
dc.contributor.author | Rimstad, Espen | |
dc.contributor.author | Olesen, Niels Jørgen | |
dc.date.accessioned | 2019-06-25T10:15:58Z | |
dc.date.available | 2019-06-25T10:15:58Z | |
dc.date.created | 2019-02-13T16:33:25Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0928-4249 | |
dc.identifier.uri | http://hdl.handle.net/11250/2602052 | |
dc.description.abstract | Piscine orthoreovirus (PRV) mediated diseases have emerged throughout salmonid aquaculture. Three PRV subtypes are currently reported as causative agents of or in association with diseases in diferent salmonid species. PRV-1causes heart and skeletal muscle infammation (HSMI) in Atlantic salmon (Salmo salar) and is associated with jaundice syndrome in farmed chinook salmon (Oncorhynchus tshawytscha). PRV-2 causes erythrocytic inclusion body syndrome (EIBS) in coho salmon in Japan. PRV-3 has recently been associated with a disease in rainbow trout (Oncorhynchus mykiss) characterized by anaemia, heart and red muscle pathology; to jaundice syndrome in coho salmon (Oncorhynchus kisutch). In this study, we conducted a 10-week long experimental infection trial in rainbow trout with purifed PRV-3 particles to assess the causal relationship between the virus and development of heart infammation. The monitoring the PRV-3 load in heart and spleen by RT-qPCR shows a progressive increase of viral RNA to a peak, followed by clearance without a measurable change in haematocrit. The development of characteristic cardiac histopathological fndings occurred in the late phase of the trial and was associated with increased expression of CD8+, indicating cytotoxic T cell proliferation. The fndings indicate that, under these experimental conditions, PRV-3 infection in rainbow trout act similarly to PRV-1 infection in Atlantic salmon with regards to immunological responses and development of heart pathology, but not in the ability to establish a persistent infection. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Piscine orthoreovirus subtype 3 (PRV-3) causes heart inflammation in rainbow trout (Oncorhynchus mykiss) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.journal | Veterinary research (Print) | nb_NO |
dc.identifier.doi | 10.1186/s13567-019-0632-4 | |
dc.identifier.cristin | 1677174 | |
cristin.unitcode | 192,16,2,0 | |
cristin.unitname | Institutt for mattrygghet og infeksjonsbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |