Blar i Faculty of Chemistry, Biotechnology and Food Science (KBM) på forfatter "Mathiesen, Geir"
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Anchoring of invasin on the surface of Lactiplantibacillus plantarum exploiting homologous N-terminal transmembrane proteins
Ljosland, Anna Bakke (Master thesis, 2021)Lactic acid bacteria (LAB) are widely used by humans for food production and preservation, and many LAB are natural inhabitants of the human gastrointestinal tract (GIT). For these reasons, LAB are generally recognized as ... -
Ankring av Chlamydia trachomatis antigener på overflaten av Lactobacillus plantarum
Myrbråten, Ine (Master thesis, 2016-11-17)Dette studiet er en del av et større prosjekt der det langsiktige målet er å utvikle slimhinnevaksiner med melkesyrebakterier som leveringsvektorer. Melkesyrebakterier ansees som gode kandidater til dette formål, da de ... -
Celleveggankring av Mycobacterium tuberculosis-antigener på overflaten til Lactobacillus plantarum
Berggreen, Hanne (Master thesis, 2020)Denne oppgaven er en del av et større forskningsprosjekt hvor det langsiktige målet er å utvikle en slimhinnevaksine mot tuberkulose, hvor melkesyrebakterier benyttes som leveringsvektor av antigener. Melkesyrebakterier ... -
Constitutive expression and anchoring of Mycobacterium tuberculosis antigens in Lactobacillus plantarum
Wiig, Solveig Birkedal (Master thesis, 2020)Tuberculosis is the leading cause of death caused by a single agent worldwide. A new and effective vaccine against this infection is therefore imperative. This study is a part of a larger project where the long-term goal ... -
Development of a CRISPR/Cas9 editing system for antigen knock-in in Lactiplantibacillus plantarum WCFS1
Haugen, Lisa Kaasbøll (Master thesis, 2022)Lactic acid bacteria (LAB) have been used in food products for hundreds of years and are commonly used in food fermentation, therapeutics, and for health promotion. They are “Generally Recognized as Safe”, have excellent ... -
Development of a non-GMO mucosal vaccine against SARS-CoV-2
Borge, Steffen (Master thesis, 2022)Lactic acid bacteria (LAB) have been proposed as a good delivery vector of surface-bound antigens, in the development of non-genetically modified organism (non-GMO) mucosal vaccines. LABs are considered good because they ... -
Identification of RseP as a receptor for hybrid bacteriocin H1 in emerging pathogen Staphylococcus haemolyticus
Bartkiewicz, Karolina Teresa (Master thesis, 2020)Staphylococcus haemolyticus is an emerging pathogen which may transfer multi-drug resistance genes to highly virulent Staphylococcus species. S. haemolyticus is a biofilm-producing bacterium and one of the most frequent ... -
Implementation of a two-plasmid CRISPR/Cas9 system in Lactobacillus plantarum : a new approach in the development of a novel vaccine against Mycobacterium tuberculosis
Wiull, Kamilla (Master thesis, 2018)Tuberculosis (TB) is the leading cause of deaths from a single infectious agent, and in 2017 1.7 million people died from TB. To date the only available vaccine against the disease is the bacille Calmette-Guèrin (BCG) ... -
Production and surface anchoring of Mycobacterium tuberculosis and SARS-CoV-2 antigens in Lactobacillus plantarum
Trondsen, Lene (Master thesis, 2021)Lactic acid bacteria (LAB) are considered good candidates for delivery of antigens because they are regarded as safe to consume by humans and can survive the rough conditions in the gastrointestinal tract, to mention some ... -
Production of potential immune modulating proteins from Methylococcus capsulatus Bath and characterization of their putative roles in inflammation
Aaen, Kristin Hovden (Master thesis, 2019)Commensal microbes have for a long time been considered important for the function and development of the human immune system. Later studies also highlight the beneficial potential of non-commensals to human health. The ... -
Secretion and anchoring of a cancer antigen in Lactobacillus plantarum
Flatin, Bjørnar Tovson Bae (Master thesis, 2017)Melanoma is one of the most lethal forms of skin cancer, and immunotherapy continues to be a hot topic for the treatment of this disease. This study is part of a larger project with the long-term goal to develop mucosal ... -
The site-2-protease RseP as a novel antimicrobial target
Kristensen, Sofie Sagvaag (PhD Thesis;2023:22, Doctoral thesis, 2023)The discovery and development of antibiotics have revolutionized modern medicine. Today, several decades after the first patients were treated with antibiotics, bacterial infections are again becoming increasingly difficult ... -
Structural and functional characterization of NcLPMO9C : a broad-specificity lytic polysaccharide monooxygenase
Trine Øye, Isaksen (PhD Thesis;2017:93, Doctoral thesis, 2017)Lignocellulose represents a major source of renewable organic matter and is of interest as feedstock for the biorefining industry, not only as a promising strategy for replacing fossil fuels in the transportation sector ... -
Studies of molecular determinants of virulence in Aliivibrio salmonicida and Vibrio anguillarum
Skåne, Anna (PhD Thesis;2021:58, Doctoral thesis, 2021)The arsenal of virulence factors possessed by a bacterium can determine its ability to infect the host and cause disease. Chitinases and chitin-active lytic polysaccharide monooxygenases (LPMOs) have been indicated to ... -
Studies of proteins involved in environmental responses of Enterococcus faecalis V583
Bøhle, Liv Borghild Anette Andreassen (PhD Thesis;2011:58, Doctoral thesis, 2011)Enterococcus faecalis has traditionally been considered a harmless inhabitant of the gastrointestinal tract of mammals. However, in the past decade E. faecalis has become a major cause of infections in hospitalized patients. ... -
Studies on proteins from Methylococcus capsulatus Bath : expression in Lactobacillus plantarum WCFS1, purification and large-scale fermentation
Sveen, Arild (Master thesis, 2016-11-21)The work described in this thesis is part of a larger project investigating the non-commensal methanotroph Methylococcus capsulatus Bath. This species has shown anti-inflammatory and obesity-reducing effects in animal ... -
Surface display of cellobiose 2- epimerases on lactic acid bacteria for conversion of lactose to epilactose
Larsen, Martin (Master thesis, 2021)An increasing body of research elicits the many health benefits imparted by the gut-associated microbiota to their host. These beneficial strains are referred to as probiotic organisms. One way to promote growth and increase ... -
The chitinolytic system of Enterococcus faecalis V583 and its putative role in virulence
Kristensen, Mariann (Master thesis, 2019)From a harmless gut commensal, Enterococcus faecalis has undergone a transition towards a multi-resistant nosocomial pathogen, posing a major threat to human health, particularly in immunocompromised individuals. The aim ... -
The Soil Bacterium Methylococcus capsulatus Bath and its Interactions with Human Immune Cells in vitro
Indrelid, Stine (PhD Thesis;2017:94, Doctoral thesis, 2017)Whereas a role for commensal microbes in the development and normal function of the immune system is well established, a potential role for environmental bacteria in regulating immunity has been widely disregarded. However, ... -
Thermodynamic aspects of processive enzymatic degradation of recalcitrant polysaccharides
Hamre, Anne Grethe (PhD Thesis;2015:46, Doctoral thesis, 2020-11-13)Carbohydrates play diverse, essential roles in all known organisms. These include roles in storage and structure as well as specific signaling roles. One carbohydrate can be linked to other carbohydrates or functional ...