Blar i Brage NMBU på forfatter "Lea, Tor"
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A study of human chitinases with respect to the importance of surface exposed aromatic residues and carbohydrate-binding modules in substrate degradation and role in inflammations
Stockinger, Linn Wilhelmsen (PhD Thesis;2015:63, Doctoral thesis, 2018-05-03)Chitin is an insoluble, linear polymer consisting of β-1, 4-linked N-acetyl-glucosamine units tightly packed in a crystalline structure. It is the second most abundant polysaccharide in nature, after cellulose, with an ... -
Adipocytter, makrofager og inflammasjon : en in vitro studie
Younis, Rafal (Master thesis, 2012-09-12)Fedme er den vanligste årsaken til insulinresistens og en rekke andre metabolske forstyrrelser, som til sammen utgjør det vi kaller metabolsk syndrom. Et kjennetegn ved fedme og utvikling av metabolsk syndrom er en svak, ... -
Characterization of cytostatic drug responses and signaling aberrations in chronic lymphocytic leukemia
Myhrvold, Ida Kristin (Master thesis, 2016-08-09)Chronic Lymphocytic Leukemia (CLL) is a heterogeneous disease with variable clinical courses. The disease is incurable, but a third to half of the patients may never need treatment. For those who need treatment, the options ... -
Coagulation factor V and doxorubicin in breast cancer
Hellenes, Mona (Master thesis, 2017)Sammenhengen mellom kreft og trombose er velkjent, likeså er sammenhengen mellom koagulasjonsaktivitet og tumorprogresjon. Ved å få økt kunnskap om de underliggende molekylære mekanismene i disse prosessene, vil man kunne ... -
Establishment of multiplexed reduced representation bisulfite sequencing protocol on T-cells from rheumatoid arthritis patients
Hansen, Eirik Elias (Master thesis, 2016-08-10)DNA methylation is an important epigenetic mark with a regulatory effect on the expression of genes. It has also been shown that individuals change their DNA methylation pattern over time. In mammals, methylation only ... -
Functional studies of ERAP2 associated with risk of autoimmune diseases
Rydland, Anne (Master thesis, 2018)Autoimmune diseases are prevalent in the global population affecting approximately 5-10% worldwide, with increasing incidence. The complexity of these diseases has made diagnostic assessment problematic, as they vary in ... -
Generation of MHC II Streptamers for gluten-specific CD4+ T cells
Risnes, Louise Fremgaard (Master thesis, 2012-10-16)Coeliac disease is a chronic inflammatory disorder of the small intestine due to inappropriate immune responses to gluten. Disease-associated HLA-DQ2.5 molecules are complexed with deamidated gluten epitopes displayed on ... -
In vitro characterization of commercial and potential probiotic lactic acid bacteria : interactions with human cells
Jensen, Hanne (PhD Thesis;2014:92, Doctoral thesis, 2014)Lactic acid bacteria (LAB), especially bacteria belonging to the genus Lactobacillus, are recognized as common inhabitants of the human gastrointestinal tract and have received considerable attention in the last decades ... -
In vitro digestion of caprine whey proteins by human gastrointestinal juices : Effect of whey hydrolysates and peptides on in vitro cell responses
Ulleberg, Ellen Kathrine (PhD Thesis;2011:70, Doctoral thesis, 2011)The objectives of this thesis were to characterise human gastrointestinal juices, to identify peptides produced after in vitro digestion of whey proteins by these juices, and to screen for immunomodulating properties of ... -
Methylococcus capsulatus og interaksjon med humane monocytter og monocytt-deriverte dendrittiske celler
Floer, Linn (Master thesis, 2012-09-05)Inflammatorisk tarmsykdom viser et komplisert og sammensatt sykdomsbilde med miljø-, genetisk predisposisjon- og immunforstyrrende faktorer som ligger til grunn for utvikling av sykdommen. Pasienter med inflammatorisk ... -
Molekylære mekanismer i samspillet mellom Toll-liknende reseptor 4 (TLR4) og gallesyrereseptor (TGR5) i en human monocyttcellelinje
Haugbro, Tarjei (Master thesis, 2012-10-03)Det har blitt vist at det vil oppstå en svak inflammatorisk respons etter et måltid. Det har også blitt vist økte nivåer av LPS i plasma etter et måltid og en hypotese går ut på at økte nivåer av LPS kan være med å bidra ... -
Risk assessment of BRCA1 variants with unknown clinical significance
Langerud, Jonas (Master thesis, 2017)Brystkreft er den mest utbredte kreftformen blant kvinner og er ansvarlig for 14 % av kreftrelaterte dødsfall i verden. Omlag 10 % av krefttilfellene kan tilskrives sykdomsgivende kimcellevarianter, av disse stammer 30 % ... -
Studies on proteins from Methylococcus capsulatus Bath : expression in Lactobacillus plantarum WCFS1, purification and large-scale fermentation
Sveen, Arild (Master thesis, 2016-11-21)The work described in this thesis is part of a larger project investigating the non-commensal methanotroph Methylococcus capsulatus Bath. This species has shown anti-inflammatory and obesity-reducing effects in animal ... -
The role of coagulation factor V in breast cancer
Anthi, Aina Karen (Master thesis, 2016-07-26)In addition to the well-known link between cancer and risk of thrombotic diseases, it is known that increased coagulation activity is associated with tumor progression. Studying the underlying molecular mechanisms could ... -
The Soil Bacterium Methylococcus capsulatus Bath and its Interactions with Human Immune Cells in vitro
Indrelid, Stine (PhD Thesis;2017:94, Doctoral thesis, 2017)Whereas a role for commensal microbes in the development and normal function of the immune system is well established, a potential role for environmental bacteria in regulating immunity has been widely disregarded. However, ...