dc.contributor.author | Jensen, Benjamin Anderschou Holbech | |
dc.contributor.author | Holm, Jacob B. | |
dc.contributor.author | Larsen, Ida S. | |
dc.contributor.author | von Burg, Nicole | |
dc.contributor.author | Derer, Stefanie | |
dc.contributor.author | Sonne, Si B. | |
dc.contributor.author | Pærrgaard, Simone I. | |
dc.contributor.author | Damgaard, Mads V. | |
dc.contributor.author | Indrelid, Stine Hufthammer | |
dc.contributor.author | Rivollier, Aymeric | |
dc.contributor.author | Agrinier, Anne-Laure | |
dc.contributor.author | Sulek, Karolina | |
dc.contributor.author | Arnoldussen, Yke Jildouw | |
dc.contributor.author | Fjære, Even | |
dc.contributor.author | Marette, André | |
dc.contributor.author | Angell, Inga Leena | |
dc.contributor.author | Rudi, Knut | |
dc.contributor.author | Treebak, Jonas Thue | |
dc.contributor.author | Madsen, Lise | |
dc.contributor.author | Åkesson, Caroline Piercey | |
dc.contributor.author | Agace, William | |
dc.contributor.author | Sina, Christian | |
dc.contributor.author | Kleiveland, Charlotte Ramstad | |
dc.contributor.author | Kristiansen, Karsten | |
dc.contributor.author | Lea, Tor Erling | |
dc.date.accessioned | 2021-09-30T11:00:44Z | |
dc.date.available | 2021-09-30T11:00:44Z | |
dc.date.created | 2021-06-10T12:17:53Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Nature Communications. 2021, 12 . | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/2786591 | |
dc.description.abstract | Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis. | |
dc.language.iso | eng | |
dc.title | Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.pagenumber | 19 | |
dc.source.volume | 12 | |
dc.source.journal | Nature Communications | |
dc.identifier.doi | 10.1038/s41467-021-21408-9 | |
dc.identifier.cristin | 1915052 | |
dc.relation.project | Norges forskningsråd: 267655 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |