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dc.contributor.authorRoyan, Muhammad Rahmad
dc.contributor.authorSiddique, Khadeeja
dc.contributor.authorCsucs, Gergely
dc.contributor.authorPuchades, Maja
dc.contributor.authorNourizadeh-Lillabadi, Rasoul
dc.contributor.authorBjaalie, Jan G.
dc.contributor.authorHenkel, Christiaan
dc.contributor.authorWeltzien, Finn-Arne
dc.contributor.authorFontaine, Romain
dc.date.accessioned2022-04-11T11:52:14Z
dc.date.available2022-04-11T11:52:14Z
dc.date.created2021-12-02T17:09:45Z
dc.date.issued2021
dc.identifier.citationFrontiers in Endocrinology. 2021, .
dc.identifier.issn1664-2392
dc.identifier.urihttps://hdl.handle.net/11250/2990933
dc.description.abstractIn vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes via the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and comprehensive knowledge of the spatial distribution of those endocrine cell types is required to better understand their physiological functions. Using medaka as a model and several combinations of multicolor fluorescence in situ hybridization, we present the first 3D atlas revealing the glandwide distribution of seven endocrine cell populations: lactotropes, thyrotropes, Lh and Fsh gonadotropes, somatotropes, and pomca-expressing cells (corticotropes and melanotropes) in the anterior pituitary of a teleost fish. By combining in situ hybridization and immunofluorescence techniques, we deciphered the location of corticotropes and melanotropes within the pomca-expressing cell population. The 3D localization approach reveals sexual dimorphism of tshba-, pomca-, and lhb-expressing cells in the adult medaka pituitary. Finally, we show the existence of bi-hormonal cells coexpressing lhb-fshb, fshb-tshba and lhb-sl using single-cell transcriptomics analysis and in situ hybridization. This study offers a solid basis for future comparative studies of the teleost pituitary and its functional plasticity.
dc.language.isoeng
dc.title3D Atlas of the Pituitary Gland of the Model Fish Medaka (Oryzias latipes)
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber17
dc.source.journalFrontiers in Endocrinology
dc.identifier.doi10.3389/fendo.2021.719843
dc.identifier.cristin1963800
dc.relation.projectNorges forskningsråd: 255601
dc.relation.projectNorges forskningsråd: 251307
dc.relation.projectNorges forskningsråd: 248828
dc.relation.projectEC/H2020/945539
dc.relation.projectNorges forskningsråd: 269774 INCF
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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