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dc.contributor.authorGrønnestad, Randi
dc.contributor.authorSchlenk, Daniel
dc.contributor.authorKrøkje, Åse
dc.contributor.authorJaspers, Veerle
dc.contributor.authorJenssen, Bjørn Munro
dc.contributor.authorCoffin, Scott
dc.contributor.authorBertotto, Luísa Becker
dc.contributor.authorGiroux, Marissa
dc.contributor.authorLyche, Jan Ludvig
dc.contributor.authorArukwe, Augustine
dc.date.accessioned2021-10-28T06:29:48Z
dc.date.available2021-10-28T06:29:48Z
dc.date.created2021-01-07T13:51:46Z
dc.date.issued2020
dc.identifier.issn0048-9697
dc.identifier.urihttps://hdl.handle.net/11250/2826102
dc.description.abstractPerfluoroalkyl substances (PFAS) are contaminants that are applied in a wide range of consumer products, including ski products. The present study investigated the neuro-dopamine (DA) and cellular steroid hormone homeostasis of wild Bank voles (Myodes glareolus) from a skiing area in Norway (Trondheim), in relation to tissue concentrations of PFAS. We found a positive association between brain DA concentrations and the concentration of several PFAS, while there was a negative association between PFAS and dopamine receptor 1 (dr1) mRNA. The ratio between DA and its metabolites (3,4-dihydroxyphenylacetic acid: DOPAC and homovanillic acid: HVA) showed a negative association between DOPAC/DA and several PFAS, suggesting that PFAS altered the metabolism of DA via monoamine oxidase (Mao). This assumption is supported by an observed negative association between mao mRNA and PFAS. Previous studies have shown that DA homeostasis can indirectly regulate cellular estrogen (E2) and testosterone (T) biosynthesis. We found no association between DA and steroid hormone levels, while there was a negative association between some PFAS and T concentrations, suggesting that PFAS might affect T through other mechanisms. The results from the current study indicate that PFAS may alter neuro-DA and steroid hormone homeostasis in Bank voles, with potential consequences on reproduction and general health.
dc.language.isoengen_US
dc.titleAlteration of neuro-dopamine and steroid hormone homeostasis in wild Bank voles in relation to tissue concentrations of PFAS at a Nordic skiing areaen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionacceptedVersion
dc.source.volume756en_US
dc.source.journalScience of the Total Environmenten_US
dc.source.issue143745en_US
dc.identifier.doihttps://doi.org/10.1016/j.scitotenv.2020.143745
dc.identifier.cristin1867087
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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