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dc.contributor.authorJohanson, Silje Modahl
dc.contributor.authorRopstad, Erik
dc.contributor.authorØstby, Gunn Charlotte
dc.contributor.authorAleksandersen, Mona
dc.contributor.authorZamaratskaia, Galia
dc.contributor.authorBoge, Gudrun Seeberg
dc.contributor.authorHalsne, Ruth
dc.contributor.authorTrangerud, Cathrine
dc.contributor.authorLyche, Jan Ludvig
dc.contributor.authorBerntsen, Hanne Friis
dc.contributor.authorZimmer, Karin Elisabeth
dc.contributor.authorVerhaegen, Steven
dc.date.accessioned2021-10-01T10:43:43Z
dc.date.available2021-10-01T10:43:43Z
dc.date.created2021-06-15T10:53:55Z
dc.date.issued2021
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/2786957
dc.description.abstractThe ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdeveloped systems of metabolism and excretion. The present study aimed to characterize the effect of in utero and lactational exposure to a human relevant mixture of POPs on the female mammary gland, ovarian folliculogenesis and liver function in CD-1 offspring mice. Dams were exposed to the mixture through the diet at Control, Low or High doses (representing 0x, 5000x and 100 000x human estimated daily intake levels, respectively) from weaning and throughout mating, gestation, and lactation. Perinatally exposed female offspring exhibited altered mammary gland development and a suppressed ovarian follicle maturation. Increased hepatic cytochrome P450 enzymatic activities indirectly indicated activation of nuclear receptors and potential generation of reactive products. Hepatocellular hypertrophy was observed from weaning until 30 weeks of age and could potentially lead to hepatotoxicity. Further studies should investigate the effects of human relevant mixtures of POPs on several hormones combined with female reproductive ability and liver function.
dc.language.isoeng
dc.titlePerinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.volume16
dc.source.journalPLOS ONE
dc.source.issue6
dc.identifier.doi10.1371/journal.pone.0252954
dc.identifier.cristin1915853
dc.relation.projectNorges forskningsråd: 204361
dc.relation.projectNorges forskningsråd: 21307
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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