γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis
dc.contributor.author | Monin, L. | |
dc.contributor.author | Ushakov, D. S. | |
dc.contributor.author | Arnesen, Henriette | |
dc.contributor.author | Bah, N. | |
dc.contributor.author | Jandke, A. | |
dc.contributor.author | Muñoz-Ruiz, M. | |
dc.contributor.author | Carvalho, J. | |
dc.contributor.author | Joseph, S. | |
dc.contributor.author | Alemeida, B. C. | |
dc.contributor.author | Green, M. J. | |
dc.contributor.author | Nye, E. | |
dc.contributor.author | Hatano, S* | |
dc.contributor.author | Yoshikai, Y. | |
dc.contributor.author | Curtis, M. | |
dc.contributor.author | Carlsen, Harald | |
dc.contributor.author | Steinhoff, U. | |
dc.contributor.author | Boysen, Preben | |
dc.contributor.author | Hayday, Adrian | |
dc.date.accessioned | 2021-05-04T08:29:26Z | |
dc.date.available | 2021-05-04T08:29:26Z | |
dc.date.created | 2020-12-17T07:41:41Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Mucosal Immunology. 2020, 13 969-981. | en_US |
dc.identifier.issn | 1933-0219 | |
dc.identifier.uri | https://hdl.handle.net/11250/2753415 | |
dc.description.abstract | This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier reports, most cells expressed a canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting with earlier reports, uterine γδ T cells were not obviously intraepithelial, being more akin to sub-epithelial Vγ6Vδ1+ T cells at several other anatomical sites. By contrast to other tissues however, the uterine compartment also included non-Vγ6+, IFN-γ-producing cells; was strikingly enriched in young mice; expressed genes hitherto associated with the uterus, including the progesterone receptor; and did not require microbes for development and/or maintenance. This notwithstanding, γδ T-cell deficiency severely impaired resistance to reproductive tract infection by Candida albicans, associated with decreased responses of IL-17-dependent neutrophils. These findings emphasise tissue-specific complexities of different mucosal γδ cell compartments, and their evident importance in lymphoid stress-surveillance against barrier infection. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 969-981 | en_US |
dc.source.volume | 13 | en_US |
dc.source.journal | Mucosal Immunology | en_US |
dc.identifier.doi | 10.1038/s41385-020-0305-7 | |
dc.identifier.cristin | 1860815 | |
dc.relation.project | EC/H2020/792383 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |