dc.contributor.author | Yaron, Jordan R. | |
dc.contributor.author | Ambadapadi, Sriram | |
dc.contributor.author | Zhang, Liqiang | |
dc.contributor.author | Chavan, Ramani N. | |
dc.contributor.author | Tibbetts, Scott A. | |
dc.contributor.author | Keinan, Shahar | |
dc.contributor.author | Varsani, Arvind | |
dc.contributor.author | Maldonado, Juan | |
dc.contributor.author | Kraberger, Simona | |
dc.contributor.author | Tafoya, Amanda M. | |
dc.contributor.author | Bullard, Whitney L. | |
dc.contributor.author | Kilbourne, Jacquelyn | |
dc.contributor.author | Stern-Harbutte, Alison | |
dc.contributor.author | Krajmalnik-Brown, Rosa | |
dc.contributor.author | Munk, Barbara H. | |
dc.contributor.author | Koppang, Erling Olaf | |
dc.contributor.author | Lim, Efrem S. | |
dc.contributor.author | Lucas, Alexandra R. | |
dc.date.accessioned | 2020-11-11T14:11:24Z | |
dc.date.available | 2020-11-11T14:11:24Z | |
dc.date.created | 2020-10-21T13:12:22Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Scientific Reports. 2020,10(1), 1079-1084 | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/2687460 | |
dc.description.abstract | Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR−/−) mice. In prior work, treatment with myxomavirus-derived Serp-1 or a derivative peptide S-7 (G305TTASSDTAITLIPR319) induced immune protection, reduced disease severity and improved survival after MHV-68 infection. Here, we investigate the gut bacterial microbiome in MHV-68 infection. Antibiotic suppression markedly accelerated MHV-68 pathology causing pulmonary consolidation and hemorrhage, increased mortality and specific modification of gut microbiota. Serp-1 and S-7 reduced pulmonary pathology and detectable MHV-68 with increased CD3 and CD8 cells. Treatment efficacy was lost after antibiotic treatments with associated specific changes in the gut bacterial microbiota. In summary, transkingdom host-virus-microbiome interactions in gammaherpesvirus infection influences gammaherpesviral infection severity and reduces immune modulating therapeutic efficacy. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 1079-1084 | en_US |
dc.source.volume | 10 | en_US |
dc.source.journal | Scientific Reports | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1038/s41598-020-59269-9 | |
dc.identifier.cristin | 1841195 | |
dc.source.articlenumber | 2371 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |