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dc.contributor.authorReveco Urzua, Felipe Eduardo
dc.contributor.authorHofossæter, Mette Eline
dc.contributor.authorKovi, Mallikarjuna Rao
dc.contributor.authorMydland, Liv Torunn
dc.contributor.authorÅnestad, Ragnhild
dc.contributor.authorSørby, Randi
dc.contributor.authorPress, Charles McLean
dc.contributor.authorLagos Rojas, Leidy Ximena
dc.contributor.authorØverland, Margareth
dc.identifier.citationPLOS ONE. 2019, 14 (12), .en_US
dc.description.abstractMicrobial ingredients such as Candida utilis yeast are known to be functional protein sources with immunomodulating effects whereas soybean meal causes soybean meal-induced enteritis in the distal intestine of Atlantic salmon (Salmo salar L.). Inflammatory or immunomodulatory stimuli at the local level in the intestine may alter the plasma proteome profile of Atlantic salmon. These deviations can be helpful indicators for fish health and, therefore potential tools in the diagnosis of fish diseases. The present work aimed to identify local intestinal tissue responses and changes in plasma protein profiles of Atlantic salmon fed inactive dry Candida utilis yeast biomass, soybean meal, or combination of soybean meal based diet with various inclusion levels of Candida utilis. A fishmeal based diet was used as control diet. Inclusion of Candida utilis yeast to a fishmeal based diet did not alter the morphology, immune cell population or gene expression of the distal intestine. Lower levels of Candida utilis combined with soybean meal modulated immune cell populations in the distal intestine and reduced the severity of soybean meal-induced enteritis, while higher inclusion levels of Candida utilis were less effective. Changes in the plasma proteomic profile revealed differences between the diets but did not indicate any specific proteins that could be a marker for health or disease. The results suggest that Candida utilis does not alter intestinal morphology or induce major changes in plasma proteome, and thus could be a high-quality alternative protein source with potential functional properties in diets for Atlantic salmon.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCandida utilis yeast as a functional protein source for Atlantic salmon (Salmo salar L.): Local intestinal tissue and plasma proteome responsesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalPLOS ONEen_US
dc.relation.projectNorges forskningsråd: 237841en_US
dc.relation.projectNorges forskningsråd: 239003en_US
cristin.unitnameInstitutt for husdyr- og akvakulturvitenskap
cristin.unitnameInstitutt for basalfag og akvamedisin
cristin.unitnameInstitutt for plantevitenskap

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Navngivelse 4.0 Internasjonal
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