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dc.contributor.authorHelgeland, Hanna
dc.contributor.authorSodeland, Marte
dc.contributor.authorZoric, Nina
dc.contributor.authorTorgersen, Jacob Seilø
dc.contributor.authorGrammes, Fabian
dc.contributor.authorMoen, Thomas
dc.contributor.authorKjøglum, Sissel
dc.contributor.authorLien, Sigbjørn
dc.contributor.authorVåge, Dag Inge
dc.date.accessioned2020-09-29T08:04:33Z
dc.date.available2020-09-29T08:04:33Z
dc.date.created2020-01-17T09:40:07Z
dc.date.issued2019
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2680141
dc.description.abstractRed coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide association study (GWAS) to identify genetic variation underlying this trait. Two SNPs on ssa26 showed strong associations to the flesh color in salmon. Two genes known to be involved in carotenoid metabolism were located in this QTL- region: beta-carotene oxygenase 1 (bco1) and beta-carotene oxygenase 1 like (bco1l). To determine whether flesh color variation is caused by one, or both, of these genes, functional studies were carried out including mRNA and protein expression in fish with red and pale flesh color. The catalytic abilities of these two genes were also tested with different carotenoids. Our results suggest bco1l to be the most likely gene to explain the flesh color variation observed in this population.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh coloren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.journalScientific Reportsen_US
dc.identifier.doi10.1038/s41598-019-56438-3
dc.identifier.cristin1775438
dc.relation.projectUniversitetet i Agder: UiA-CCRen_US
cristin.unitcode192,10,1,0
cristin.unitnameInstitutt for husdyr- og akvakulturvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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