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dc.contributor.authorHaatveit, Hanne Merethe
dc.contributor.authorHodneland, Kjartan
dc.contributor.authorBraaen, Stine
dc.contributor.authorHansen, Elisabeth Furuseth
dc.contributor.authorNyman, Ingvild Berg
dc.contributor.authorDahle, Maria
dc.contributor.authorFrost, Petter
dc.contributor.authorRimstad, Espen
dc.date.accessioned2018-12-12T15:44:28Z
dc.date.available2018-12-12T15:44:28Z
dc.date.created2018-12-09T17:28:37Z
dc.date.issued2018
dc.identifier.citationVaccine. 2018, 36 (50), 7599-7608.nb_NO
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/11250/2577484
dc.description.abstractPiscine orthoreovirus (PRV) causes heart- and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). Erythrocytes are the main target cells for PRV. HSMI causes significant economic losses to the salmon aquaculture industry, and there is currently no vaccine available. PRV replicates and assembles within cytoplasmic structures called viral factories, mainly organized by the non-structural viral protein mNS. In two experimental vaccination trials in Atlantic salmon, using DNA vaccines expressing different combinations of PRV proteins, we found that expression of the non-structural proteins mNS combined with the cell attachment protein r1 was associated with an increasing trend in lymphocyte marker gene expression in spleen, and induced moderate protective effect against HSMI.nb_NO
dc.language.isoengnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleDNA vaccine expressing the non-structural proteins of Piscine orthoreovirus delay the kinetics of PRV infection and induces moderate protection against heart -and skeletal muscle inflammation in Atlantic salmon (Salmo salar)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber7599-7608nb_NO
dc.source.volume36nb_NO
dc.source.journalVaccinenb_NO
dc.source.issue50nb_NO
dc.identifier.doi10.1016/j.vaccine.2018.10.094
dc.identifier.cristin1640786
cristin.unitcode192,16,2,0
cristin.unitnameInstitutt for mattrygghet og infeksjonsbiologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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