• Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge 

      Heegaard, Peter M.H.; Tranulis, Michael A.; Salvesen, Øyvind; Espenes, Arild; Reiten, Malin Rokseth; Ersdal, Cecilie; Skovgaard, Kerstin (Journal article; Peer reviewed, 2016)
    • Demyelinating polyneuropathy in goats lacking prion protein. 

      Skedsmo, Fredrik Strebel; Malachin, Giulia; Våge, Dag Inge; Hammervold, Mie Marie; Salvesen, Øyvind; Ersdal, Cecilie; Ranheim, Birgit; Stafsnes, Marit Hallvardsdotter; Bartosova, Zdenka; Bruheim, Per; Jäderlund, Karin Hultin; Matiasek, Kaspar; Espenes, Arild; Tranulis, Michael A. (Peer reviewed; Journal article, 2019)
      Studies in mice with ablation of Prnp, the gene that encodes the cellular prion protein (PrPC), have led to the hypothesis that PrPC is important for peripheral nerve myelin maintenance. Here, we have used a nontransgenic ...
    • Goats naturally devoid of PrPC are resistant to scrapie 

      Salvesen, Øyvind; Espenes, Arild; Reiten, Malin Rokseth; Vuong, Tram Thu; Malachin, Giulia; Tran, Linh Dinh Thoai; Andréoletti, Olivier; Olsaker, Ingrid; Benestad, Sylvie Lafond; Tranulis, Michael A.; Ersdal, Cecilie (Peer reviewed; Journal article, 2020)
      Prion diseases are progressive and fatal, neurodegenerative disorders described in humans and animals. According to the “protein-only” hypothesis, the normal host-encoded prion protein (PrPC) is converted into a pathological ...
    • Goats naturally devoid of PrPC are resistant to scrapie 

      Salvesen, Øyvind; Espenes, Arild; Reiten, Malin Rokseth; Vuong, Tram Thu; Malachin, Giulia; Tran, Linh Dinh Thoai; Andréoletti, Olivier; Olsaker, Ingrid; Benestad, Sylvie Lafond; Tranulis, Michael A.; Ersdal, Cecilie (Peer reviewed; Journal article, 2020)
      Prion diseases are progressive and fatal, neurodegenerative disorders described in humans and animals. According to the "protein-only" hypothesis, the normal host-encoded prion protein (PrPC) is converted into a pathological ...
    • LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface 

      Salvesen, Øyvind; Reiten, Malin Rokseth (Journal article; Peer reviewed, 2017)
    • The cellular prion protein and the inflammatory response 

      Salvesen, Øyvind (PhD Thesis;2017:81, Doctoral thesis, 2017)
      The cellular prion protein (PrPC) is known for its pivotal role in the development of prion diseases, such as Creutzfeldt-Jakob disease in humans and scrapie in small ruminants. In these diseases, PrPC is converted into a ...
    • The prion protein in neuroimmune crosstalk 

      Salvesen, Øyvind; Tazelt, Jörg; Tranulis, Michael A. (Journal article; Peer reviewed, 2018)
      The cellular prion protein (PrPC) is a medium-sized glycoprotein, attached to the cell surface by a glycosylphosphatidylinositol anchor. PrPC is encoded by a single-copy gene, PRNP, which is abundantly expressed in the ...