Blar i Brage NMBU på forfatter "Sæther, Thomas"
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Biological Evaluations, NMR Analyses, Molecular Modeling Studies, and Overview of the Synthesis of the Marine Natural Product (−)-Mucosin
Nolsøe, Jens Mortansson Jelstrup; Underhaug, Jarl; Sørskår, Åshild Moi; Antonsen, Simen; Malterud, Karl Egil; Gani, Osman; Fan, Qiong; Hjorth, Marit; Sæther, Thomas; Hansen, Trond Vidar; H. Stenstrøm, Yngve (Peer reviewed; Journal article, 2024)Natural products obtained from marine organisms continue to be a rich source of novel structural architecture and of importance in drug discovery, medicine, and health. However, the success of such endeavors depends on the ... -
Methylation-dependent SUMOylation of the architectural transcription factor HMGA2
Stabell, Marianne; Sæther, Thomas; Kjendseth, Åsmund Røhr; Gabrielsen, Odd Stokke; Myklebost, Ola (Peer reviewed; Journal article, 2021)High mobility group A2 (HMGA2) is a chromatin-associated protein involved in the regulation of stem cell function, embryogenesis and cancer development. Although the protein does not contain a consensus SUMOylation site, ... -
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist
Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Soedling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas (Journal article; Peer reviewed, 2019)The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for ... -
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist
Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Soedling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas (Journal article; Peer reviewed, 2019)The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for ...