• Demyelinating polyneuropathy in goats lacking prion protein. 

      Skedsmo, Fredrik Strebel; Malachin, Giulia; Våge, Dag Inge; Hammervold, Mie Marie; Salvesen, Øyvind; Ersdal, Cecilie; Ranheim, Birgit; Stafsnes, Marit Hallvardsdotter; Bartosova, Zdenka; Bruheim, Per; Jäderlund, Karin Hultin; Matiasek, Kaspar; Espenes, Arild; Tranulis, Michael A. (Peer reviewed; Journal article, 2019)
      Studies in mice with ablation of Prnp, the gene that encodes the cellular prion protein (PrPC), have led to the hypothesis that PrPC is important for peripheral nerve myelin maintenance. Here, we have used a nontransgenic ...
    • Goats naturally devoid of PrPC are resistant to scrapie 

      Salvesen, Øyvind; Espenes, Arild; Reiten, Malin Rokseth; Vuong, Tram Thu; Malachin, Giulia; Tran, Linh Dinh Thoai; Andréoletti, Olivier; Olsaker, Ingrid; Benestad, Sylvie Lafond; Tranulis, Michael A.; Ersdal, Cecilie (Peer reviewed; Journal article, 2020)
      Prion diseases are progressive and fatal, neurodegenerative disorders described in humans and animals. According to the “protein-only” hypothesis, the normal host-encoded prion protein (PrPC) is converted into a pathological ...
    • Goats naturally devoid of PrPC are resistant to scrapie 

      Salvesen, Øyvind; Espenes, Arild; Reiten, Malin Rokseth; Vuong, Tram Thu; Malachin, Giulia; Tran, Linh Dinh Thoai; Andréoletti, Olivier; Olsaker, Ingrid; Benestad, Sylvie Lafond; Tranulis, Michael A.; Ersdal, Cecilie (Peer reviewed; Journal article, 2020)
      Prion diseases are progressive and fatal, neurodegenerative disorders described in humans and animals. According to the "protein-only" hypothesis, the normal host-encoded prion protein (PrPC) is converted into a pathological ...
    • Loss of prion protein induces a primed state of type I interferon-responsive genes 

      Malachin, Giulia; Reiten, Malin Rokseth (Journal article; Peer reviewed, 2017)
      The cellular prion protein (PrPC) has been extensively studied because of its pivotal role in prion diseases; however, its functions remain incompletely understood. A unique line of goats has been identified that carries ...
    • Stress resilience of spermatozoa and blood mononuclear cells without prion protein 

      Reiten, Malin Rokseth; Malachin, Giulia; Kommisrud, Elisabeth; Østby, Gunn Charlotte; Waterhouse, Karin Elisabeth; Krogenæs, Anette Kristine; Kusnierczyk, Anna; Bjørås, Magnar; Jalland, Clara Maria Osnes; Nekså, Liv Heidi; Røed, Susan Skogtvedt; Stenseth, Else-Berit; Myromslien, Frøydis Deinboll; Zeremichael, Teklu Tewoldebrhan; Bakkebø, Maren Kolltveit; Espenes, Arild; Tranulis, Michael A. (Journal article; Peer reviewed, 2018)