• Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice 

      Sinioja, Tim; Bodin, Johanna Eva; Duberg, Daniel; Dirven, Hubert; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Nygaard, Unni Cecilie; Orešič, Matej; Hyötyläinen, Tuulia (Peer reviewed; Journal article, 2022)
      Introduction Autoimmune disorders such as type 1 diabetes (T1D) are believed to be caused by the interplay between several genetic and environmental factors. Elucidation of the role of environmental factors in metabolic ...
    • Pioneering an effect-based early warning system for hazardous chemicals in the environment 

      Niarchos, Georgios; Alygizakis, Nikiforos A.; Garere, Mario; Dulio, Valeria; Engwall, Magnus; Hyötyläinen, Tuulia; Kallenborn, Roland; Karakitsios, Spyros; Karakoltzidis, Achilleas; Kärrman, Anna; Lamoree, Marja H.; Larsson, Maria; Lundqvist, Johan; Mancini, Laura; Mottaghipisheh, Javad; Rostkowski, Pawel; Sarigiannis, Dimesthenis; Vorkamp, Katrin; Ahrens, Lutz (Peer reviewed; Journal article, 2024)
      Existing regulatory frameworks often prove inadequate in promptly identifying contaminants of emerging concern (CECs) and determining their impacts on biological systems at an early stage. The establishment of Early Warning ...
    • Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes 

      McGlinchey, Aidan; Sinioja, Tim; Lamichhane, Santosh; Sen, Partho; Bodin, Johanna Eva; Siljander, Heli; Dickens, Alex M.; Geng, Dawei; Carlsson, Cecilia; Duberg, Daniel; Ilonen, Jorma; Virtanen, Suvi M.; Dirven, Hubert; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Nygaard, Unni Cecilie; Orešič, Matej; Knip, Mikael; Hyötyläinen, Tuulia (Peer reviewed; Journal article, 2020)
      In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their ...