Blar i Brage NMBU på forfatter "Carlsen, Harald"
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A transgenic reporter mouse model for in vivo assessment of retinoic acid receptor transcriptional activation
Carlsen, Harald; Ebihara, Kanae; Kuwata, Nobuyo H.; Kuwata, Kazuhisa; Aydemir, Gamze; Rühl, Ralph; Blomhoff, Rune (Peer reviewed; Journal article, 2021) -
Betydningen av NOX1 for utviklingen av metabolsk syndrom i mus fôret med høyfettdiett med og uten favabønner
Hulsund, Sissel Katrine (Master thesis, 2020)Bakgrunn: Metabolsk syndrom er sterkt knyttet til fedme hvor vanligste årsak er høyfettdietter og sedativ livsstil. Fedme fører til lavgradsinflammasjon i fettvev og lever og er pådriver for insulinresistens og MetS. ... -
Calorie and protein restriction in mammals : a review and comparison on respect to aging
Nossen, Johan Noraker (Master thesis, 2016-11-21)Calorie restriction (CR), a 10-50% (typically 30%) reduction in calorie intake with adequate nutrients, is the most widely accepted intervention to delay aging and increase lifespan in many model organisms. Recently, there ... -
Can oral administration of lipopolysaccharide (LPS) exaggerate metabolic effects and inflammation imposed by a Western diet in mice?
Skogen, Vemund Heggen (Master thesis, 2019)A Western diet is an energy dense and nutrient poor diet associated with low-grade inflammatory consequences and is implicated in causing a range of non-communicable diseases (NCDs) including obesity and diabetes type 2 ... -
Coffee intake and the effects on intestinal inflammation, metabolic homeostasis and intestinal barrier function in mice
Harvei, Silje (Master thesis, 2016-09-14)Epidemiological studies have associated coffee consumption with beneficial effects including reduced risk of metabolic diseases such as type 2 diabetes. Conclusive results from experimental studies remain yet to be defined, ... -
Contribution of epigenetic and epitranscriptomic factors in gene regulation of embryonic stem cells : I. Generation of Ythdf1-3 knock-outs and characterization of their phenotypes. II. Investigating the role of a chromatin modifier, MMSET in R-loop biology
Østby, Gina Henriette; Aarseth, Katrine Råkjær (Master thesis, 2020)Both epigenetic and epitranscriptomic modifications have been revealed to impact gene regulation and are linked to numerous diseases and oncogenic reprogramming. Reversible alterations in gene expression with no effects ... -
Effect of an enriched microbial environment on maintenance of gut health and tissue homeostasis in mice
Hindhamar, Linda Kristine (Master thesis, 2020)Introduction: The house mouse, as humans and other animals, have co-evolved with the billions of microbes surrounding them and colonizing their bodies and composing their microbiota. Microbes colonizing the gut, namely the ... -
Effect of calcium on fatty acid digestibility and weight development in mice
Meling, Sebastian (Master thesis, 2021)Background: High intake of saturated fatty acids (SFA) has consistently been shown to raise low-density lipoprotein cholesterol, a known risk factor of cardiovascular disease (CVD). One of the most significant contributors ... -
Effects of a diet intervention on plasma lipopolysaccharide-binding protein in colorectal cancer patients
Van der Straeten, Sarah (Master thesis, 2019)Objective: Increased systemic level of lipopolysaccharide-binding protein (LBP) is proposed to be a biomarker of increased gut permeability. The main objective of this master thesis was to investigate whether a one year ... -
Effekt av kalsium på fordøyelse av fettsyrer og uttrykk av gener involvert i kolesterolhomeostase i mus
Uglum, Marte Andréa (Master thesis, 2021)Bakgrunn: Hjerte- og karsykdom (HKS), og særlig aterosklerotisk sykdom, er globalt en stor helsebyrde og er den ledende dødsårsaken i verden. Høye konsentrasjoner av lavtetthet-lipoprotein (LDL) i blodet er assosiert med ... -
Effekt av NOX1 og Reaktive oksygenforbindelser i tarm hos mus som fôres med høyfettdiett
Wesenberg, Eirin Haraldsdotter (Master thesis, 2020)Bakgrunn: Et velfungerende fordøyelsessystem er viktig for både mental og fysisk helse. Særlig er et kontrollert miljø og symbiotisk mikrobiom i nederste del av tynntarm svært viktig, da hovednæringsopptak skjer i dette ... -
Effekter av gluten og fruktaner på fekale inflammatoriske og mikrobiotaassosierte biomarkører hos pasienter med ikke-cøliakisk glutensensitivitet
Aspholm, Trude Elise (Master thesis, 2020)Bakgrunn og målsetning: Årsaken til og patogenesen for gastrointestinale (GI) problemer hos pasienter med ikke-cøliakisk gluten sensitivitet (NCGS) er ukjent, men pasientene opplever bedring i symptomene ved glutenfri ... -
Exploring the Therapeutic Potenital of the Leaderless Enterocins K1 and EJ97 in the Treatment of Vancomycin-Resistant Enterococcal Infection
Reinseth, Ingvild; Tønnesen, Hanne Hjorth; Carlsen, Harald; Diep, Dzung B. (Journal article; Peer reviewed, 2021) -
How does a low-FODMAP diet affect the gut microbiota composition in patients with irritable bowel syndrome?
Amundsen, Silje Søyland (Master thesis, 2016-11-17)Background: Irritable bowel syndrome (IBS) is a disorder characterized by abdominal pain, diarrhea, constipation and general discomfort. It is also characterized by a change in the composition of microorganisms in the ... -
Identification of a novel function of tankyrase : inhibition of tankyrase catalytic activity leads to increased cellular cholesterol levels
Zedell, Caroline (Master thesis, 2017)Tankyrase 1 og 2 er multifunksjonelle proteiner som har viktige roller i mange cellulære prosesser. Den mest studerte funskjonen av tankyrase er regularingen av WNT/β-catenin signalveien og tankyraseinhibitorer utforskes ... -
Identification of phospho- and total-proteome in glioma cell lines after inhibition of cyclin-dependent kinase 12 (CDK12) and cyclin-dependent kinase 13 (CDK13)
Skyrud, Nora Elise (Master thesis, 2021)Numerous factors and mechanisms control proper gene expression. Transcription regulation by RNA polymerase II (RNAPII) carboxy-terminal domain (CTD) phosphorylation influences global transcription levels and manufacture ... -
Mikrobiotaproduserte kortkjedede fettsyrer i appetittregulering og fedme : en systematisk oversikt
Biribakken, Mia (Master thesis, 2019)Obesity has gained worldwide epidemiological status, contributes to major health risks, and costs to society. For this reason, there is increasing interest for finding new methods to prevent and treat this disease. Obesity ... -
Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but Caspase-1 independent
Breyne, Koen; Cool, Steven; Demon, Dieter; Demeyre, Kristel; Vandenberghe, Tom; Vandenabeele, Peter; Carlsen, Harald; Van Den Broeck, Wim; Sanders, Niek; Meyer, Evelyne (Journal article; Peer reviewed, 2014)Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta ... -
The role of coagulation factor V in breast cancer : effect on treatment response
Lind, Sara Marie (Master thesis, 2021)Sammenhengen mellom kreft og koagulasjon er vel etablert og det er kjent at kreftpasienter har en økt risiko for å utvikle trombose. Kreftceller kan ofte uttrykke koagulasjonsfaktorer som fører til ubalanse i hemostasen ... -
The role of HCAR1 on oligodendrocyte proliferation and survival after neonatal hypoxia ischemia in mice
Austbø, Marie Landa (Master thesis, 2021)Neonatal cerebral hypoxia-ischemia (HI) is a leading cause of death and disability in infants. It is characterized by insufficient supply of blood and oxygen to the brain, resulting in cell death and tissue loss. The only ...