Browsing Brage NMBU by Author "Bjørgen, Håvard"
Now showing items 1-20 of 31
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A comprehensive transcriptional body map of Atlantic salmon unveils the vital role of the intestine in the immune system and highlights functional specialization within its compartments
Kortner, Trond M.; Afanasyev, Sergey; Koppang, Erling Olaf; Bjørgen, Håvard; Krogdahl, Åshild; Krasnov, Aleksei (Peer reviewed; Journal article, 2024)The intestine is a barrier organ that plays an important role in the immune system of Atlantic salmon. The immune functions are distributed among the diffuse gut lymphoid tissue containing diverse immune cells, and other ... -
Anatomical and pathological characteristics of ribs in the Atlantic salmon (Salmo salar L.) and its relevance to soft tissue changes
Brimsholm, Malin Helen; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Trangerud, Cathrine; Knutsen, Geir Magne; Asserson, Charlotte Finstad; Koppang, Erling Olaf; Bjørgen, Håvard (Peer reviewed; Journal article, 2023)Studies on the anatomical and pathological characteristics of ribs in farmed Atlantic salmon (Salmo salar L.) are warranted due to their possible association with red and melanized focal changes (RFC and MFC) in the fillet, ... -
Anatomy of teleost fish immune structures and organs
Bjørgen, Håvard; Koppang, Erling Olaf (Peer reviewed; Journal article, 2021)The function of a tissue is determined by its construction and cellular composition. The action of different genes can thus only be understood properly when seen in the context of the environment in which they are expressed ... -
Anatomy, immunology, digestive physiology and microbiota of the salmonid intestine: Knowns and unknowns under the impact of an expanding industrialized production
Bjørgen, Håvard; Li, Yanxian; Kortner, Trond M.; Krogdahl, Åshild; Koppang, Erling Olaf (Peer reviewed; Journal article, 2020)Increased industrialized production of salmonids challenges aspects concerning available feed resources and animal welfare. The immune system plays a key component in this respect. Novel feed ingredients may trigger ... -
Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics
Bjørgen, Håvard; Malik, Muhammad Salman; Rimstad, Espen; Vaadal, Marianne; Nyman, Ingvild Berg; Koppang, Erling Olaf; Tengs, Torstein (Peer reviewed; Journal article, 2023)Spatial transcriptomics is a technique that provides insight into gene expression profiles in tissue sections while retaining structural information. We have employed this method to study the pathological conditions related ... -
Deciphering the pathogenesis of melanized focal changes in the white skeletal muscle of farmed Atlantic salmon (Salmo salar)
Bjørgen, Håvard; Brimsholm, Malin; Asserson, Charlotte Finstad; Skaar, Kirstin; Knutsen, Geir Magne; Oaland, Øyvind; Haldorsen, Randi; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Rimstad, Espen; Kleist, Britta; Lund-Iversen, Marius; Kowalewski, Mariusz Pawel; Koppang, Erling Olaf (Peer reviewed; Journal article, 2024)Melanized focal changes (MFCs) in the fillet of farmed Atlantic salmon is a major quality concern. The changes are thought to initially appear as acute red focal changes (RFCs) that progress into chronic MFCs. Recent ... -
Dissemination of Piscine orthoreovirus-1 (PRV-1) in Atlantic Salmon (Salmo salar) during the Early and Regenerating Phases of Infection
Kannimuthu, Dhamotharan; Bjørgen, Håvard; Malik, Muhammad Salman; Nyman, Ingvild Berg; Markussen, Turhan Ali Dadasbilge; Dahle, Maria; Koppang, Erling Olaf; Wessel, Øystein; Rimstad, Espen (Peer reviewed; Journal article, 2020) -
Dissemination of piscine orthoreovirus-1 (PRV-1) in atlantic salmon (salmo salar) during the early and regenerating phases of infection
Kannimuthu, Dhamotharan; Bjørgen, Håvard; Malik, Muhammad Salman; Nyman, Ingvild Berg; Markussen, Turhan Ali Dadasbilge; Dahle, Maria K.; Koppang, Erling Olaf; Wessel, Øystein; Rimstad, Espen (Peer reviewed; Journal article, 2020)Piscine orthoreovirus-1 (PRV-1) can cause heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar), but the line of events from infection, pathologic change, and regeneration has not been ... -
Ectopic epithelial cell clusters in salmonid intestine are associated with inflammation
Bjørgen, Håvard; Koppang, Erling Olaf; Gunnes, Gjermund; Hordvik, Ivar; Moldal, Torfinn; Kaldhusdal, Magne; Dale, Ole Bendik (Journal article; Peer reviewed, 2018) -
Effekten av turbiditet i RAS-anlegg på gjellehelse målt i antall slimceller i gjellene hos atlantisk laks i settefiskproduksjon
Figenschou, Alexander J. Hat.; Hillestad, Linn-Anett (Student paper, others, 2019)I dette studiet ble det studert sammenhengen mellom turbiditet og antall slimceller i gjellene til atlantisk laks. Hypotesen var at høy turbiditet (og dermed lav siktdybde i vannkarene) i RAS-anlegg kan føre til økt mekanisk ... -
Erythroid Progenitor Cells in Atlantic Salmon (Salmo salar) May Be Persistently and Productively Infected with Piscine Orthoreovirus (PRV)
Malik, Muhammad Salman; Bjørgen, Håvard; Kannimuthu, Dhamotharan; Wessel, Øystein; Koppang, Erling Olaf; Di Cicco, Emiliano; Hansen, Elisabeth Furuseth; Dahle, Maria; Rimstad, Espen (Peer reviewed; Journal article, 2019)Piscine orthoreovirus (PRV-1) can cause heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). The virus targets erythrocytes in the acute peak phase, followed by cardiomyocytes, before the ... -
Erythroid Progenitor Cells in Atlantic Salmon (Salmo salar) May Be Persistently and Productively Infected with Piscine Orthoreovirus (PRV)
Malik, Muhammad Salman; Bjørgen, Håvard; Kannimuthu, Dhamotharan; Wessel, Øystein; Koppang, Erling Olaf; Di Cicco, Emiliano; Hansen, Elisabeth Furuseth; Dahle, Maria K; Rimstad, Espen (Journal article; Peer reviewed, 2019)Piscine orthoreovirus (PRV-1) can cause heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). The virus targets erythrocytes in the acute peak phase, followed by cardiomyocytes, before the ... -
Evaluating Atlantic Salmon (Salmo salar) as a Natural or Alternative Host for Piscine Myocarditis Virus (PMCV) Infection
Nyman, Ingvild Berg; Wessel, Øystein; Bjørgen, Håvard; Alarcon, Marta; Tengs, Torstein; Rimstad, Espen (Peer reviewed; Journal article, 2024) -
High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue
Dalum, Alf Seljenes; Kraus, Aurora; Khan, Shanawaz; Davydova, Erna; Rigaudeau, Dimitri; Bjørgen, Håvard; Lopez Porras, Adrian; Griffiths, Gareth Wyn; Wiegertjes, Geert F.; Koppang, Erling Olaf; Salinas, Irene; Boudinot, Pierre; Resseguier, Julien (Journal article; Peer reviewed, 2021)The zebrafish is extensively used as an animal model for human and fish diseases. However, our understanding of the structural organization of its immune system remains incomplete, especially the mucosa-associated lymphoid ... -
High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue
Dalum, Alf Seljenes; Kraus, Aurora; Khan, Shanawaz; Davydova, Erna; Rigaudeau, Dimitri; Bjørgen, Håvard; Lopez Porras, Adrian; Griffiths, Gareth Wyn; Wiegertjes, Geert F.; Koppang, Erling Olaf; Salinas, Irene; Boudinot, Pierre; Resseguier, Julien (Journal article; Peer reviewed, 2021)The zebrafish is extensively used as an animal model for human and fish diseases. However, our understanding of the structural organization of its immune system remains incomplete, especially the mucosa-associated lymphoid ... -
IgM+ and IgT+ B Cell Traffic to the Heart during SAV Infection in Atlantic Salmon
Bakke, Anne Flore; Bjørgen, Håvard; Koppang, Erling Olaf; Frost, Petter; Afanasyev, Sergey; Boysen, Preben; Krasnov, Aleksei; Lund, Hege (Peer reviewed; Journal article, 2020)B cells of teleost fish differentiate in the head kidney, and spleen, and either remain in the lymphatic organs or move to the blood and peripheral tissues. There is limited knowledge about piscine B cell traffic to sites ... -
Immunopathological characterization of red focal changes in Atlantic salmon (Salmo salar) white muscle
Bjørgen, Håvard; Kumar, Subramani; Gunnes, Gjermund; Press, Charles McLean; Rimstad, Espen; Koppang, Erling Olaf (Peer reviewed; Journal article, 2020)Farmed Atlantic salmon (Salmo salar) are prone to various conditions affecting the quality of the fillet. A well-known but so far poorly understood condition is the focal red changes in muscle, often referred to as ... -
Inflammatory conditions in the musculoskeletal system of salmonids in Norwegian aquaculture in relation to melanized changes
Brimsholm, Malin Helen (PhD Thesis;2023:79, Doctoral thesis, 2023)Norwegian salmonid aquaculture has become one of Norway's largest industries. With a yearly export of 1.25 million tons, Norway is the largest producer of Atlantic salmon worldwide. Norway also has a significant production ... -
Melanised focal changes in Atlantic salmon : interactions between infection and immunity
Bjørgen, Håvard (PhD Thesis;2021:82, Doctoral thesis, 2022)Atlantic salmon (Salmo salar) farming has increased rapidly in Norway over the last 50 years. However, the large-scale farming of salmon battles serious health problems. There are currently many adverse conditions threatening ... -
Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV)
Bjørgen, Håvard; Haldorsen, Randi; Oaland, Øyvind; Kvellestad, Agnar Ståle; Kannimuthu, Dhamotharan; Rimstad, Espen; Koppang, Erling Olaf (Journal article; Peer reviewed, 2019)