Blar i Brage NMBU på forfatter "Carlsen, Harald"
-
How does a low-FODMAP diet affect the gut microbiota composition in patients with irritable bowel syndrome?
Amundsen, Silje Søyland (Master thesis, 2016-11-17)Background: Irritable bowel syndrome (IBS) is a disorder characterized by abdominal pain, diarrhea, constipation and general discomfort. It is also characterized by a change in the composition of microorganisms in the ... -
Identification of a novel function of tankyrase : inhibition of tankyrase catalytic activity leads to increased cellular cholesterol levels
Zedell, Caroline (Master thesis, 2017)Tankyrase 1 og 2 er multifunksjonelle proteiner som har viktige roller i mange cellulære prosesser. Den mest studerte funskjonen av tankyrase er regularingen av WNT/β-catenin signalveien og tankyraseinhibitorer utforskes ... -
Identification of phospho- and total-proteome in glioma cell lines after inhibition of cyclin-dependent kinase 12 (CDK12) and cyclin-dependent kinase 13 (CDK13)
Skyrud, Nora Elise (Master thesis, 2021)Numerous factors and mechanisms control proper gene expression. Transcription regulation by RNA polymerase II (RNAPII) carboxy-terminal domain (CTD) phosphorylation influences global transcription levels and manufacture ... -
Impact of dietary components and reactive oxygen species (ROS) in the colon and its microbiota in a low-grade inflammation mouse model
Papoutsis, Dimitrios (PhD Thesis;2022:58, Doctoral thesis, 2022)Background: Various factors, including dietary components, the gut microbiota and host responses, are imperative for gut health. Optimal interactions between diet, gut microbiota and host are suggested to be important to ... -
Intestinal effect of faba bean fractions in WD-fed mice treated with low dose of DSS
Papoutsis, Dimitrios; Rocha, Sergio; Herfindal, Anne Mari; Bøhn, Siv Kjølsrud; Carlsen, Harald (Peer reviewed; Journal article, 2022) -
Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections
Grønseth, Torstein; Ovchinnikov, Kirill; Carlsen, Harald; Saltyte Benth, Jurate; Diep, Dzung B.; Von Unge, Magnus; Silvola, Juha Tapio (Peer reviewed; Journal article, 2022)The study aimed to evaluate the antibacterial efficacy of Lugol's solution 5% and Gentian violet 1% against methicillin-resistant Staphylococcus aureus (MRSA) biofilm in vivo. The bactericidal efficacy for treatment of ... -
Mikrobiotaproduserte kortkjedede fettsyrer i appetittregulering og fedme : en systematisk oversikt
Biribakken, Mia (Master thesis, 2019)Obesity has gained worldwide epidemiological status, contributes to major health risks, and costs to society. For this reason, there is increasing interest for finding new methods to prevent and treat this disease. Obesity ... -
Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but Caspase-1 independent
Breyne, Koen; Cool, Steven; Demon, Dieter; Demeyre, Kristel; Vandenberghe, Tom; Vandenabeele, Peter; Carlsen, Harald; Van Den Broeck, Wim; Sanders, Niek; Meyer, Evelyne (Journal article; Peer reviewed, 2014)Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta ... -
Pharmacological tools to study transcriptional addictions in cancer
Iliev, Hristo Kostadinov (Master thesis, 2022)Unfortunately, genetic diseases such as cancer are becoming more common among the global popu-lation, and only in 2020 approximately 19 million new cases were discovered, and 10 million lives were lost. With median overall ... -
The role of coagulation factor V in breast cancer : effect on treatment response
Lind, Sara Marie (Master thesis, 2021)Sammenhengen mellom kreft og koagulasjon er vel etablert og det er kjent at kreftpasienter har en økt risiko for å utvikle trombose. Kreftceller kan ofte uttrykke koagulasjonsfaktorer som fører til ubalanse i hemostasen ... -
The role of HCAR1 on oligodendrocyte proliferation and survival after neonatal hypoxia ischemia in mice
Austbø, Marie Landa (Master thesis, 2021)Neonatal cerebral hypoxia-ischemia (HI) is a leading cause of death and disability in infants. It is characterized by insufficient supply of blood and oxygen to the brain, resulting in cell death and tissue loss. The only ... -
Rollen til det ROS-genererende enzymet NADPH oksidase 1 ved lavgrads inflammasjon i tykktarm
Herfindal, Anne Mari (Master thesis, 2018)Bakgrunn: I kroppen dannes reaktive oksygenforbindelser (ROS) i så godt som alle typer celler og vev, hvor de utfører mange ulike og viktige funksjoner. I denne sammenheng ansees enzymer kalt NADPH oksidaser (NOX-enzymer) ... -
Single-cell analysis of ER-positive breast cancer treated with letrozole and ribociclib
Vander-Elst, Karoline Rapp (Master thesis, 2022)Breast cancer is the most widespread cancer in the world, accounting for 25% of all female cancers. There is a high inter- and intra-tumor heterogeneity in breast cancer which makes it challenging to optimize the treatment ... -
Small intestinal microbiota – Regulation by reactive oxygen species and influence of diet
Kielland, Chrysoula (PhD Thesis;2022:5, Doctoral thesis, 2022)Over the last years multiple studies have analyzed the impact of intestinal microbiota on health. Certain changes in the composition of the microbial population in the intestine have been associated with several diseases ... -
Successful development of bacteriocins into therapeutic formulation for treatment of MRSA skin infection in a murine model
Ovchinnikov, Kirill; Kranjec, Christian; Thorstensen, Tage; Carlsen, Harald; Diep, Dzung B. (Peer reviewed; Journal article, 2020)The emergence of antibiotic-resistant pathogens has caused a serious worldwide problem in infection treatment in recent years. One of the pathogens is methicillin-resistant Staphylococcus aureus (MRSA), which is a major ... -
Systematic evaluation of RT-qPCR kits and protocols for detection and quantitation of microRNAs
Andersen, Sofie Strøm (Master thesis, 2019)MicroRNAs (miRNAs) are small single-stranded non-coding RNAs with an average length of ~ 22 nucleotides. The main function of miRNA is post-transcriptional regulation of gene expression by targeting specific mRNAs. The ... -
The functional role of coagulation factor V in liver cancer
McCoig, Cathrine (Master thesis, 2018)Sammenhengen mellom koagulasjon og kreft er velkjent. Kreftpasienter har en dokumentert økt risiko for trombose, og kreftceller kan også frigi kreft-prokoagulanter og mikropartikler som direkte aktiverer koagulasjonssystemet. ... -
The role of coagulation factor V in breast cancer
Fredhjem, Marianne Staff (Master thesis, 2018)Pasienter med kreftsykdommer har en økt risiko for thromboemboliske sykdommer, og det er også etablert en sammenheng mellom koagulasjons faktorer og økt risiko for tumor progresjon. En bedre forståelse av de underliggende ... -
The role of the rseP gene in systemic infection of mice
Djuvik, Ingve Gudvin Røv (Master thesis, 2019)The group of antimicrobial substances collectively known as antibiotics is humanity's foremost weapon against a range of pathogenic bacteria but is also getting increasingly compromised with the rise of antibiotic resistance. ... -
The ROS-generating enzyme NADPH oxidase 1 modulates the colonic microbiota but offers minor protection against dextran sulfate sodium-induced low-grade colon inflammation in mice
Herfindal, Anne Mari; Rocha, Sergio; Papoutsis, Dimitrios; Bøhn, Siv Kjølsrud; Carlsen, Harald (Peer reviewed; Journal article, 2022)