dc.contributor.author | Kranjec, Christian | |
dc.contributor.author | Ovchinnikov, Kirill | |
dc.contributor.author | Grønseth, Torstein | |
dc.contributor.author | Ebineshan, Kumar | |
dc.contributor.author | Srikantam, Aparna | |
dc.contributor.author | Diep, Dzung B. | |
dc.date.accessioned | 2021-02-05T14:41:26Z | |
dc.date.available | 2021-02-05T14:41:26Z | |
dc.date.created | 2021-01-18T17:52:15Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | npj Biofilms and Microbiomes. 2020, 6(1) | en_US |
dc.identifier.issn | 2055-5008 | |
dc.identifier.uri | https://hdl.handle.net/11250/2726484 | |
dc.description.abstract | 1463 Accesses
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Abstract
Antibiotic-resistant and biofilm-associated infections brought about by methicillin-resistant Staphylococcus aureus (MRSA) strains is a pressing issue both inside as well as outside nosocomial environments worldwide. Here, we show that a combination of two bacteriocins with distinct structural and functional characteristics, garvicin KS, and micrococcin P1, showed a synergetic antibacterial activity against biofilms produced in vitro by S. aureus, including several MRSA strains. In addition, this bacteriocin-based antimicrobial combination showed the ability to restore the sensitivity of the highly resilient MRSA strain ATCC 33591 to the β-lactam antibiotic penicillin G. By using a combination of bacterial cell metabolic assays, confocal and scanning electron microscopy, we show that the combination between garvicin KS, micrococcin P1, and penicillin G potently inhibit cell viability within S. aureus biofilms by causing severe cell damage. Together these data indicate that bacteriocins can be valuable therapeutic tools in the fight against biofilm-associated MRSA infections. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | A bacteriocin-based antimicrobial formulation to effectively disrupt the cell viability of methicillin-resistant Staphylococcus aureus (MRSA) biofilms | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 13 | en_US |
dc.source.volume | 6 | en_US |
dc.source.journal | npj Biofilms and Microbiomes | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1038/s41522-020-00166-4 | |
dc.identifier.cristin | 1873628 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |